Rabbit Secondary Antibodies
ABclonal Technology NFYA Rabbit mAb
The protein encoded by this gene is one subunit of a trimeric complex forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes Subunit A associates with a tight dimer composed of the B and C subunits resulting in a trimer that binds to DNA with high specificity and affinity The sequence specific interactions of the complex are made by the A subunit suggesting a role as the regulatory subunit In addition there is evidence of post-transcriptional regulation in this gene product either by protein degradation or control of translation Further regulation is represented by alternative splicing in the glutamine-rich activation domain with clear tissue-specific preferences for the two isoforms
ABclonal Technology FGF23 Rabbit mAb
This gene encodes a member of the fibroblast growth factor family of proteins which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes The product of this gene regulates phosphate homeostasis and transport in the kidney The full-length functional protein may be deactivated via cleavage into N-terminal and C-terminal chains Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR) Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC)
Abcam Rabbit Anti-Mouse IgG H&L Alexa Fluor 568 preadsorbed
Rabbit Anti-Mouse IgG H&L Alexa Fluor 568 preadsorbed
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology CCL17 Rabbit mAb
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16 Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes The CC cytokines are proteins characterized by two adjacent cysteines The cytokine encoded by this gene displays chemotactic activity for T lymphocytes but not monocytes or granulocytes The product of this gene binds to chemokine receptors CCR4 and CCR8 This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells
Cayman Chemical PLAPNTerm RabbIt Monclon 100uL
An inhibitor of SIK2 (IC50 50s 21.63 and 6.63 nM respectively) inhibits TNF-a secretion in RAW 264.7 cells (IC50 ~2.5 UM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 UM inhibits growth of 10 ovarian cancer cell lines (IC50s 0.8-2.6 UM) and increases sensitivity of eight of them to paclitaxel halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 UM has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
ABclonal Technology CD105/Endoglin Rabbit mAb
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity Mutations in this gene cause hereditary hemorrhagic telangiectasia also known as Osler-Rendu-Weber syndrome 1 an autosomal dominant multisystemic vascular dysplasia This gene may also be involved in preeclampsia and several types of cancer Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Cayman Chemical CD79aCTerm RabbIt Monclo 100uL
A BET family protein inhibitor inhibits binding of BRD2 BRD3 and BRD4 to an acetylated histone H4 peptide in vitro decreases Myc levels in and inhibits proliferation of AML DLBCL and MM cells reduces tumor growth in AML DLBCL and MM mouse xenograft models reduces tumor growth when administered alone or in combination with docetaxel or MDV 3100 in a 22Rv1 CRPC mouse xenograft model
ABclonal Technology ABflo 647 Rabbit anti- CD59a
Predicted to enable complement binding activity Involved in several processes including negative regulation of angiogenesis negative regulation of fibroblast growth factor production and negative regulation of vascular endothelial growth factor receptor signaling pathway Acts upstream of or within negative regulation of activation of membrane attack complex Located in external side of plasma membrane Is expressed in several structures including Meckel s cartilage nervous system neural retina skeleton and testis Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer Orthologous to human CD59 (CD59 molecule (CD59 blood group))
ABclonal Technology H2-Ab1 Rabbit mAb
Enables several functions including peptide antigen binding activity protein antigen binding activity and toxic substance binding activity Involved in several processes including B cell affinity maturation cellular response to interferon-gamma and positive regulation of T-helper 1 type immune response Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response Located in Golgi apparatus endosome and external side of plasma membrane Is integral component of membrane Part of MHC class II protein complex Is expressed in lung metanephros and thymus primordium Orthologous to human HLA-DQB2 (major histocompatibility complex class II DQ beta 2)
ABclonal Technology Wnt16 Rabbit mAb
The WNT gene family consists of structurally related genes which encode secreted signaling proteins These proteins have been implicated in oncogenesis and in several developmental processes including regulation of cell fate and patterning during embryogenesis This gene is a member of the WNT gene family It contains two transcript variants diverging at the 5 termini These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter They are differentially expressed in normal tissues one of which (variant 2) is expressed at significant levels only in the pancreas whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney placenta brain heart and spleen
ABclonal Technology TrkB Rabbit mAb
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family This kinase is a membrane-bound receptor that upon neurotrophin binding phosphorylates itself and members of the MAPK pathway Signalling through this kinase leads to cell differentiation Mutations in this gene have been associated with obesity and mood disorders Alternative splicing results in multiple transcript variants
ABclonal Technology Calretinin Rabbit mAb
This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily Members of this protein family have six EF-hand domains which bind calcium This protein plays a role in diverse cellular functions including message targeting and intracellular calcium buffering It also functions as a modulator of neuronal excitability and is a diagnostic marker for some human diseases including Hirschsprung disease and some cancers Alternative splicing results in multiple transcript variants
Cayman Chemical LDL RECPTR RabbIt MoncLNa 50uL
A phenolic glucoside with in vitro neuroprotective activity reduces glutamate-induced neurotoxicity by 19.3 in PC12 cells at 10 UM
ABclonal Technology WFS1 Rabbit mAb
This gene encodes a transmembrane protein which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain pancreas heart and insulinoma beta-cell lines Mutations in this gene are associated with Wolfram syndrome also called DIDMOAD (Diabetes Insipidus Diabetes Mellitus Optic Atrophy and Deafness) an autosomal recessive disorder The disease affects the brain and central nervous system Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6) also known as DFNA14 or DFNA38 Alternatively spliced transcript variants have been found for this gene
